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Monascin

CAT: 0804-HY-N6641-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6641-01Size:1 mg
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Description
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice) . Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor) . Monascin is a Nrf2 activator and PPARγ agonist[1][2].
CAS Number
21516-68-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Keap1-Nrf2; PPAR
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/monascin.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1C(CCCCC)=O)O[C@]2(C)[C@]1([H])CC(C=C(/C=C/C)OC3)=C3C2=O
Molecular Formula
C21H26O5
Molecular Weight
358.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Akihisa T, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice) . Chem Biodivers. 2005 Oct;2 (10) :1305-9.|[2]Lee CL, et al. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006 Oct;72 (6) :1254-62.|[3]Shi YX, Chen WS. Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-κB/p65 pathway. Iran J Basic Med Sci. 2020;23 (4) :461-468. |[4]Hsu WH, et al. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Toxicol Appl Pharmacol. 2013 Nov 1;272 (3) :842-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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