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DR2313

CAT: 0804-HY-105692-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105692-02Size:10 mg
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Description
DR2313 is a potent, selective, competitive and brain-penetrant inhibitor of poly (ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively. DR2313 exhibits neuroprotective effects on ischemic injuries in vitro and in vivo[1][2].
CAS Number
284028-90-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dr2313.html
Purity
99.66
Solubility
DMSO : 12.5 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C1C(CSCC2)=C2NC(C)=N1
Molecular Formula
C8H10N2OS
Molecular Weight
182.25
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Nakajima H, et, al. A newly synthesized poly (ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J Pharmacol Exp Ther. 2005 Feb;312 (2) :472-81.|[2]Xu Z, et, al. Endonuclease G does not play an obligatory role in poly (ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia. Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299 (1) :R215-21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP2

Chemical Information

2-Methyl-3,5,7,8-tetrahydrothiopyrano(4,3-d)pyrimidine-4-one

a neuroprotective agent; structure in first source

CAS Number284028-90-6
PubChem CID135522417
IUPAC Name2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
Molecular FormulaC8H10N2OS
Molecular Weight182.25
XLogP-0.2
Topological Polar Surface Area66.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count12
Formal Charge0
Complexity293
SMILES
CC1=NC2=C(CSCC2)C(=O)N1
InChI
InChI=1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
InChIKey
HRYKZAKEAVZGJD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Methyl-3,5,7,8-tetrahydrothiopyrano(4,3-d)pyrimidine-4-one
CAS: 284028-90-6
CID: 135522417
Formula: C8H10N2OS
MW: 182.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight182.25
XLogP3-0.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass182.05138412
Monoisotopic Mass182.05138412
Topological Polar Surface Area66.8 Ų
Heavy Atom Count12
Formal Charge0
Complexity293
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
1771-5DR2313
sc-202756PARP Inhibitor XI, DR2313

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