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GC376 (sodium)

CAT: 0804-HY-100721-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100721-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GC376 sodium is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM, respectively.
CAS Number
1416992-39-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/GC376.html
Purity
99.96
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@](C(S(=O)(O[Na])=O)O)([H])CC1C(NCC1)=O)=O)OCC2=CC=CC=C2
Molecular Formula
C21H30N3NaO8S
Molecular Weight
507.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim Y, et al. Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses. J Virol. 2012 Nov;86 (21) :11754-62.|[2]Takahashi D, et al. Structural and inhibitor studies of norovirus 3C-like proteases. Virus Res. 2013 Dec 26;178 (2) :437-44.|[3]Yunjeong Kim, et al. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog. 2016 Mar 30;12 (3) :e1005531.|[4]Pedersen NC, et al. Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. J Feline Med Surg. 2017 Sep 1:1098612X17729626.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
T5188-01GC376 sodium
A22221-25GC376 sodium 25mg
A22221-50GC376 sodium 50mg
A22221-500GC376 sodium 500mg
A22221-100GC376 sodium 100mg
A22221-10GC376 sodium 10mg
A22221-5GC376 sodium 5mg
A22221-10mM-DGC376 sodium 10mM * 1mL in DMSO
abx283475-01GC376

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