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Clorsulon (Standard)

CAT: 0804-HY-B0488R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0488R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clorsulon (Standard) is the analytical standard of Clorsulon. This product is intended for research and analytical applications. Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep[1][2][3][4][5][6].
CAS Number
60200-06-8
Product Name Alternative
L631529 (Standard) ; MK401 (Standard)
UNSPSC
12352005
Target
Parasite; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/clorsulon-standard.html
Smiles
O=S(C1=C(/C(Cl)=C(Cl)\Cl)C=C(N)C(S(=O)(N)=O)=C1)(N)=O
Molecular Formula
C8H8Cl3N3O4S2
Molecular Weight
380.66
References & Citations
[1]Mrozik, H., et al., 4-amino-6- (trichloroethenyl) -1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20 (9) : p. 1225-7.|[2]Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92 (3) : p. 232-41.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
No Development Reported

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