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Clorsulon

CAT: 0804-HY-B0488-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0488-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep[1][2][3][4][5][6].
CAS Number
60200-06-8
Product Name Alternative
L631529; MK401
UNSPSC
12352005
Hazard Statement
H319
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/clorsulon.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=C(/C(Cl)=C(Cl)\Cl)C=C(N)C(S(=O)(N)=O)=C1)(N)=O
Molecular Formula
C8H8Cl3N3O4S2
Molecular Weight
380.66
Precautions
H319
References & Citations
[1]Mrozik, H., et al., 4-amino-6- (trichloroethenyl) -1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20 (9) : p. 1225-7.|[2]Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92 (3) : p. 232-41.|[3]Meaney M, et al. A scanning electron microscope study on the route of entry of clorsulon into the liver fluke, Fasciola hepatica. Parasitol Res. 2005 Jan;95 (2) :117-28. |[4]Blanco-Paniagua E, et al. Role of the Abcg2 Transporter in Secretion into Milk of the Anthelmintic Clorsulon: Interaction with Ivermectin. Antimicrob Agents Chemother. 2023 May 17;67 (5) :e0009523.|[5]Rehbein S, et al. Plasma pharmacokinetics of clorsulon following administration of a single subcutaneous or intravenous injection to cattle. J Vet Pharmacol Ther. 2024 Mar;47 (2) :87-94. |[6]Lankas GR, et al. Induction of reversible urothelial cell hyperplasia in rats by clorsulon, a flukicide with weak carbonic anhydrase inhibitory activity. Food Chem Toxicol. 1992 Apr;30 (4) :297-306.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Schistosome

Alternative Products

CatalogName
FA20519-01Clorsulon
AR-C03323-01Clorsulon-13C6

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