MK2-IN-3

MK2-IN-3

• CAS Number: 724711-21-1
• UNSPSC Description: MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo[1].
• Target Antigen: MAPKAPK2 (MK2)
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mk2-in-3.html
• Purity: 99.70
• Solubility: DMSO : 62.5 mg/mL (ultrasonic)
• Smiles: O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1
• Molecular Weight: 340.386
• References & Citations: [1]Anderson DR, et, al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported