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HNPMI

CAT: 0804-HY-162148-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162148-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HNPMI is an inhibitor of EGFR and has cytotoxic effects on tumor cells. HNPMI can downregulate the protein levels of osteopontin, survivin and cathepsin S, leading to apoptosis. HNPMI also regulates BCL-2/BAX and p53 in CRC cell lines to inhibit tumorigenesis[1].
CAS Number
1980848-48-3
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hnpmi.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C(N2CCC3=C2C=CC=C3)C4=CC([N+]([O-])=O)=CC=C4O)C=C1
Molecular Formula
C22H20N2O3
Molecular Weight
360.41
References & Citations
[1]Kandhavelu J, et al. A novel EGFR inhibitor, HNPMI, regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer. Br J Pharmacol. 2024 Jan;181 (1) :107-124.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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