Kynurenic acid (Standard)

Kynurenic acid (Standard)

• CAS Number: 492-27-3
• UNSPSC Description: Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
• Target Antigen: Apoptosis; CXCR; Endogenous Metabolite; GPR35 ; iGluR
• Type: Reference Standards
• Related Pathways: Apoptosis;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Inflammation/Immunology; Neurological Disease; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/kynurenic-acid-standard.html
• Purity: 98.87
• Solubility: DMSO : 9 mg/mL (ultrasonic;warming)
• Smiles: O=C(C1=NC2=CC=CC=C2C(O)=C1)O
• Molecular Weight: 189.17
• References & Citations: [1]Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281(31):22021-8.|[2]Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85(8):1027-32.|[3]Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39(1):6-13.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: Phase 1