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Kynurenic acid-d5

CAT: 0804-HY-100806SSize: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100806SSize:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8[1][2].
CAS Number
350820-13-2
Product Name Alternative
Quinurenic acid-d5
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; CXCR; Endogenous Metabolite; GPR35 ; iGluR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology; Neurological Disease; Endocrinology
Purity
99.64
Solubility
0.1 M NaOH : 12.5mg/mL (ultrasonic; adjust pH to 9 with NaOH) |10 mM in DMSO
Smiles
OC1=C([2H])C(C(O)=O)=NC2=C1C([2H])=C([2H])C([2H])=C2[2H]
Molecular Formula
C10H2D5NO3
Molecular Weight
194.20
Precautions
H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Wang J, et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem. 2006 Aug 4;281 (31) :22021-8.|[3]Albuquerque EX, et al. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol. 2013 Apr 15;85 (8) :1027-32.|[4]Małaczewska J, et al. Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol. 2014;39 (1) :6-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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