RV-1729

CAT: 0804-HY-106006Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-106006Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-δ (PI3Kδ) . RV-1729 identifies inhibition of the PI3K isotype by quantifying the release of phosphatidylinositol 3,4, 5-triphosphate (PIP3) (IC50=12 nM), showing twice the selectivity for PI3Kδ relative to PI3Kγ. RV-1729 is also 16 times more selective to PI3Kα. RV-1729 regulates immune and inflammatory responses by inhibiting PI3Kδ. RV-1729 can be used in studies of asthma and chronic obstructive pulmonary disease (COPD) [1].
CAS Number
[1293915-42-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/rv-1729.html
Smiles
O=C1N(CC2=CC=CC=C2Cl)C(CN3N=C(C4=CC=CC(O)=C4)C5=C(N)N=CN=C53)=NC6=C1C(C#CCCCC(N(CCOC)CCOC)=O)=CC=C6
Molecular Formula
C39H39ClN8O5
Molecular Weight
735.23
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Norman P. Evaluation of WO2013136076: two crystalline forms of the phosphatidylinositol 3-kinase-δ inhibitor RV-1729[J]. Expert Opinion on Therapeutic Patents, 2014, 24 (4) : 471-475.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

Related Products

CatalogName
HY-P4129Rabies Virus Matrix Protein Fragment (RV-MAT)
HY-153533-01GRL-1720
HY-114266-01UC-1728
HY-10532-01SRT 1720
HY-125471-01VK-1727
HY-125547EIDD-1723
HY-15145-01SRT 1720 (monohydrochloride)
HY-10532A-01SRT 1720 (hydrochloride)
HY-15145A-01SRT 1720 (dihydrochloride)
HY-100927-01Ro 20-1724

Alternative Products

CatalogName
M11188-01RV-1729
MBS5798683AZ 1729
A99401RV VP6
A45-Ab4RV mAb4
A45-Ab1RV mAb1
A45-Ab2RV mAb2
A45-Ab3RV mAb3
581775RV 538
592138Rafivirumab (RV)
591872Foravirumab (RV)

Popular Products