EIDD-1723

CAT: 0804-HY-125547Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-125547Size:1 Each
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Description
EIDD-1723 is a Progesterone (HY-N0437) analogues, that binds progesterone receptor (PR) with an IC50 of 2.25 μM. EIDD-1723 is the prodrug of EIDD-036 (HY-17649) . EIDD-1723 may exert its neuroprotective effects not solely through progesterone receptor (PR) -dependent pathways but also via non-genomic mechanisms, such as modulation of inflammatory responses and oxidative stress. EIDD-1723 can be used for the study of traumatic brain injury (TBI) [1][2][3].
CAS Number
[1659302-89-2]
UNSPSC
12352211
Target
Progesterone Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Endocrinology; Neurological Disease
Smiles
C[C@@]12[C@](CC[C@@H]2/C(C)=N/OCOP(O[Na])(O[Na])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C
Molecular Formula
C22H32NNa2O6P
Molecular Weight
483.45
References & Citations
[1]Wali B, et al. Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats. Neuropharmacology. 2016 Oct;109:148-158.|[2]Fritzemeier RG, et al. Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury. J Med Chem. 2023 Apr 27;66 (8) :5397-5414.|[3]Sayeed I, et al. Development of a novel progesterone analog in the treatment of traumatic brain injury. Neuropharmacology. 2019 Feb;145 (Pt B) :292-298.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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