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Acriflavine

CAT: 0804-HY-100575-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100575-01Size:50 mg
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Description
Acriflavine (Acriflavinium chloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine is an antiseptic agent. Acriflavine is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2[1][2][3][4][5][6].
CAS Number
8048-52-0
Product Name Alternative
Acriflavinium (chloride) 3,6-Acridinediamine mix
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Fluorescent Dye; Fungal; HIF/HIF Prolyl-Hydroxylase; Monocarboxylate Transporter; SARS-CoV
Type
Dye Reagents
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Acriflavine.html
Purity
98.0
Solubility
H2O : ≥ 25 mg/mL
Smiles
NC(C=C1)=CC(C1=C2)=NC3=C2C=CC(N)=C3.NC(C=C4)=CC(C4=C5)=[N+](C)C6=C5C=CC(N)=C6.[Cl-]
Molecular Formula
C14H14ClN3
Molecular Weight
259.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Chan LM, et al. Interaction of acriflavine with DNA and RNA. J Mol Biol. 1969 Mar 28;40 (3) :491-5.|[2]Thomas Meinelt, et al. Effects of Calcium Content and Humic Substances on the Toxicity of Acriflavine to Juvenile Zebrafish Danio rerio. Journal of Aquatic Animal Health, 14:1, 35-38.|[3]Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7 (1) :4292.|[4]Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22 (3) :139-45.|[5]Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Aug 3;130 (5) :655-665.|[6]Napolitano V, et al. Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses. Cell Chem Biol. 2022 May 19;29 (5) :774-784.e8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
Phase 4

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