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5HPP-33

CAT: 0804-HY-114545-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114545-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5HPP-33 is an inhibitor for tubulin polymerization with IC50 of 8.1 μM. 5HPP-33 inhibits the proliferation of leukemia cell and multiple myeloma cells with IC50 of 1-10 μM, arrests the cell cycle at G2/M phase, and induces apoptosis[1][2].
CAS Number
[105624-86-0]
UNSPSC
12352005
Hazard Statement
H410
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5hpp-33.html
Smiles
O=C1C2=CC=C(C=C2C(N1C3=C(C(C)C)C=CC=C3C(C)C)=O)O
Molecular Formula
C20H21NO3
Molecular Weight
323.39
Precautions
P273-P391-P501
References & Citations
[1]Inatsuki S, et al. Tubulin-polymerization inhibitors derived from thalidomide. Bioorg Med Chem Lett. 2005 Jan 17;15 (2) :321-5. |[2]Iguchi T, et al. 5HPP-33, a Novel Tubulin-Polymerization Inhibitor Derived from Thalidomide, Directly Inhibits Proliferation and Induces Apoptosis of Human Multiple Myeloma Cells[J]. Blood, 2005, 106 (11) : 1586.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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