Ac2-12

• Description :

  Ac2-12, an annexin/lipocortin 1 (LC1) -mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].

• UNSPSC :

  12352209

• Target :

  Annexin A

• Type :

  Peptides

• Related Pathways :

  Cytoskeleton

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ac2-12.html

• Purity :

  99.87

• Solubility :

  H2O : 50 mg/mL (ultrasonic)

• Smiles :

  [Ac-AMVSEFLKQAW]

• Molecular Formula :

  C63H94N14O17S

• Molecular Weight :

  1351.57

• References & Citations :

  [1]L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95 (24) :14535-9.|[2]M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158 (6) :1969-73.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [256447-08-2]