EGFR Antibody (Ascites) [AMM02492G]

• Background:

  Tissue Location: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

• Synonyms:

  Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1

• Gene Name:

  HGNC:3236

• Gene ID:

  1956

• UniProt:

  P00533

• Chromosomal Location:

  Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein Endosome Endosome membrane. Nucleus. Note=In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029) . Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029) . Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055)

• Applications:

  WB

• Dilution:

  WB--1:2000

• Form:

  Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

• Function:

  27909601080572527153536279096076791048144591941997515611079122970492715353620837704179090292715353611116146116026041148358920462955

• Molecular Weight:

  134277

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EGFR Antibody (Ascites) [AMM02492G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1956

• Uniprot URL:

  https://www.uniprot.org/uniprot/P00533