ZEB1 antibody (Ascites) [AMM22114G]

• Background:

  Tissue Location: Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level) . Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas

• Synonyms:

  Zinc finger E-box-binding homeobox 1, NIL-2-A zinc finger protein, Negative regulator of IL2, Transcription factor 8, TCF-8, ZEB1, AREB6, TCF8

• Gene Name:

  ZEB1

• Gene ID:

  6935

• UniProt:

  P37275

• Chromosomal Location:

  Nucleus

• Applications:

  WB, FC

• Dilution:

  WB--1:500~16000 FC--1:10~50

• Form:

  Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

• Function:

  Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3') . Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

• Molecular Weight:

  124074

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ZEB1 antibody (Ascites) [AMM22114G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=6935

• Uniprot URL:

  https://www.uniprot.org/uniprot/P37275