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AZD6538

CAT: 0804-HY-119282-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-119282-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD6538 is a potent, selective and brain penetrant mGluR5 negative allosteric modulator. AZD6538 inhibits DHPG (HY-12598A) -stimulated intracellular Ca2+ release in HEK cells expressing rat or human mGluR5, with IC50 values of 3.2 and 13.4 nM for rat mGluR5 and human mGluR5, respectively. AZD6538 can be used for the research of neuropathic pain[1].
CAS Number
[453566-30-8]
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/azd6538.html
Purity
99.21
Solubility
DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
N#CC1=CC=C(N=C1)C2=NOC(C3=CC(F)=CC(C#N)=C3)=N2
Molecular Formula
C15H6FN5O
Molecular Weight
291.24
References & Citations
[1]Raboisson P, et al. Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg Med Chem Lett. 2012 Nov 15;22 (22) :6974-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5

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