Tubulin polymerization-IN-56

• UNSPSC Description:

  Tubulin polymerization-IN-56 (compound 8l), an indazole derivative, is a potent tubulin polymerization inhibitor through interacting with the colchicine site, resulting in cell cycle arrest and cellular apoptosis. polymerization-IN-56 reduces cell migration and leads to more potent inhibition of tumor growth in vivo[1].

• Target Antigen:

  Apoptosis; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tubulin-polymerization-in-56.html

• Solubility:

  DMSO : 40 mg/mL (ultrasonic)

• Smiles:

  CC1=CC=C(C2=CC=C3C(N(C4=CC(OC)=C(OC)C(OC)=C4)N=C3)=C2)C=N1.Cl

• Molecular Weight:

  411.88

• References & Citations:

  [1]Ying-Jie Cui, et al. The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors. Eur J Med Chem. 2023 Oct 18:262:115870.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2966790-98-5