RAB11B Antibody (C-term) [APR03759G]

• Synonyms:

  Ras-related protein Rab-11B, GTP-binding protein YPT3, RAB11B, YPT3

• Gene Name:

  RAB11B

• Gene ID:

  9230

• UniProt:

  Q15907

• Chromosomal Location:

  Recycling endosome membrane {ECO:0000250|UniProtKB:P46638}; Lipid-anchor {ECO:0000250|UniProtKB:P46638}; Cytoplasmic side {ECO:0000250|UniProtKB:P46638}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35509}; Lipid-anchor {ECO:0000250|UniProtKB:O35509}; Cytoplasmic side {ECO:0000250|UniProtKB:O35509}. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus.

• Applications:

  IHC-P, WB

• Dilution:

  WB--1:1000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.

• Molecular Weight:

  24489

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RAB11B Antibody (C-term) [APR03759G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=9230

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15907