Rab11b (NM_008997) Mouse Recombinant Protein

• Background:

  The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  A730055L17Rik

• Gene ID:

  19326

• UniProt:

  P46638, Q78ZJ8

• Accession Number mRNA:

  NM_008997

• Chromosomal Location:

  17 17.98 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  24.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Rab11b

• Species:

  Mouse

• Protein ID:

  NP_033023

• Overview:

  Purified recombinant protein of Mouse RAB11B, member RAS oncogene family (Rab11b), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/19326

• Uniprot URL:

  https://www.uniprot.org/uniprot/P46638

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008997

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_033023