(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione

(E)-5-(2-Bromovinyl)pyrimidine-2,4(1H,3H)-dione

• CAS Number: 69304-49-0
• UNSPSC Description: (E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/e-5-2-bromovinyl-pyrimidine-2-4-1h-3h-dione.html
• Smiles: O=C1NC(C(/C=C/Br)=CN1)=O
• Molecular Weight: 217.02
• References & Citations: [1]De Clercq, et al. Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. J. Med. Chem. 29(2), 213-217 (1986).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported