Abd110

CAT: 0804-HY-157767Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-157767Size:1 Each

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Description

Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs[1].

CAS Number

3021581-79-0

UNSPSC

12352005

Target

ATM/ATR; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/abd110.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC(C2=CC=C(S(=O)(NCCCCCC(NCCCC#CC3=CC=CC4=C3CN(C(CC5)C(NC5=O)=O)C4=O)=O)=O)C=C2)=CN=C1N)NC6=CC=CC=C6

Molecular Formula

C41H42N8O7S

Molecular Weight

790.89

References & Citations

[1]Abdallah M Alfayomy, et al. Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the ataxia telangiectasia and RAD3-related (ATR) kinase. Eur J Med Chem. 2024 Mar 5:267:116167.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ATR; Cereblon

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