Mouse Ephb4 Antibody (C-term) [AMM06438G]

• Background:

  Tissue Location: Expressed in various organ systems, including lung, liver, kidney, intestine, muscle and heart (PubMed:7478528) . Expressed in myogenic progenitor cells (PubMed:27446912)

• Synonyms:

  Ephrin type-B receptor 4, Developmental kinase 2, mDK-2, Hepatoma transmembrane kinase, Tyrosine kinase MYK-1, Ephb4, Htk, Mdk2, Myk1

• Gene Name:

  Ephb4

• Gene ID:

  13846

• UniProt:

  P54761

• Chromosomal Location:

  Cell membrane {ECO:0000250|UniProtKB:P54760}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54760}

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.

• Molecular Weight:

  108848

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Ephb4 Antibody (C-term) [AMM06438G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=13846

• Uniprot URL:

  https://www.uniprot.org/uniprot/P54761