Ephb4 (NM_010144) Mouse Recombinant Protein

• Background:

  Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI042935; Htk; MDK2; Myk1; Tyro11

• Gene ID:

  13846

• UniProt:

  P54761, Q3V1K8, Q8C7S3

• Accession Number mRNA:

  NM_010144

• Chromosomal Location:

  5 G2

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  109.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ephb4

• Species:

  Mouse

• Protein ID:

  NP_034274

• Overview:

  Purified recombinant protein of Mouse Eph receptor B4 (Ephb4), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/13846

• Uniprot URL:

  https://www.uniprot.org/uniprot/P54761

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_010144

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_034274