RAB11FIP2 Antibody (Center) [AMM07428G]

• Synonyms:

  Rab11 family-interacting protein 2, Rab11-FIP2, NRip11, RAB11FIP2, KIAA0941

• Gene Name:

  RAB11FIP2

• Gene ID:

  22841

• UniProt:

  Q7L804

• Chromosomal Location:

  Cell projection, phagocytic cup. Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane

• Applications:

  WB, IHC-P, FC

• Dilution:

  WB--1:1000 IHC-P--1:100~500 FC--1:10~50

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.

• Molecular Weight:

  58279

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RAB11FIP2 Antibody (Center) [AMM07428G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=22841

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q7L804