RAB11 FIP2 (RAB11FIP2) (NM_014904) Human Recombinant Protein

• Background:

  A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  NRip11; Rab11-FIP2

• Gene ID:

  22841

• UniProt:

  Q7L804

• Accession Number mRNA:

  NM_014904

• Chromosomal Location:

  10q26.11

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Endocytosis

• Field of Research:

  Endocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl

• Molecular Weight:

  58.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RAB11FIP2

• Species:

  Human

• Protein ID:

  NP_055719

• Overview:

  Recombinant protein of human RAB11 family interacting protein 2 (class I) (RAB11FIP2), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/22841

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q7L804

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_014904

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_055719