NCOA2 Antibody (Center) [APR08626G]

• Synonyms:

  Nuclear receptor coactivator 2, NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2, NCOA2, BHLHE75, SRC2, TIF2

• Gene Name:

  NCOA2

• Gene ID:

  10499

• UniProt:

  Q15596

• Chromosomal Location:

  Nucleus.

• Applications:

  WB

• Dilution:

  WB--1:1000

• Function:

  Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) . Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity) .

• Molecular Weight:

  159157

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NCOA2 Antibody (Center) [APR08626G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10499

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15596