NCOA2 (NM_006540) Human Recombinant Protein

• Background:

  The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

• Synonyms:

  BHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2

• Gene ID:

  10499

• UniProt:

  Q15596

• Accession Number mRNA:

  NM_006540

• Chromosomal Location:

  8q13.3

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

• Function:

  Druggable Genome

• Molecular Weight:

  31.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NCOA2

• Species:

  Human

• Protein ID:

  NP_006531

• Overview:

  Purified recombinant protein of Human nuclear receptor coactivator 2 (NCOA2), Met1-Ile280, with N-terminal His tag, expressed in E. coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/10499

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q15596

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006540

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006531