NGEF Antibody (C-term) [AMM06677G]

• Background:

  Tissue Location: Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.

• Synonyms:

  Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF

• Gene Name:

  NGEF

• Gene ID:

  25791

• UniProt:

  Q8N5V2

• Chromosomal Location:

  Cytoplasm. Membrane. Cell projection, growth cone. Note=Associated with membranes. Localizes to axonal growth cones (By similarity)

• Applications:

  WB

• Dilution:

  WB--1:2000

• Function:

  Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) .

• Molecular Weight:

  82496

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NGEF Antibody (C-term) [AMM06677G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=25791

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8N5V2