PTOTAC HSD17B13 degrader 1

• CAS Number:

  3046195-01-8

• UNSPSC Description:

  PTOTAC HSD17B13 degrader 1 (compound 1) is a PROTAC targeting 17β-HSD 13 (HSD17B13). PTOTAC HSD17B13 degrader 1 is composed of PROTAC target protein ligand HSD17B13 degrader 2 (HY-159662) (red part), PROTAC Linker tert-Butyl 5-bromoisoindoline-2-carboxylate (HY-W003696) (black part) and E3 ubiquitin ligase ligand E3 ligase Ligand 31 (HY-159660) (blue part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 114 (HY-159661)[1].

• Target Antigen:

  17β-HSD; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ptotac-hsd17b13-degrader-1.html

• Smiles:

  O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C(CCCN4CC5=CC(C6=CC7=NN([C@@H]8CC[C@H](CC8)CNC(C9=C(C(F)=C(C(F)=C9)O)F)=O)C=C7C=C6)=CC=C5C4)C=C3N1C.Cl

• Molecular Weight:

  856.33

• References & Citations:

  [1]Preparation of 3-fluoro-4-hydroxybenzamide-containing inhibitors and/or degraders and their therapeutic uses. World Intellectual Property Organization, WO2024127297 A1. 2024-06-20.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported