SEMA3E Antibody (C-term) [APR13240G]

• Background:

  Tissue Location: Detected in neurons in the thalamus. Detected in embryonic vasculature. Developing lungs, developing skeletal elements and ventral horns of the developing neural tube. Correlates positively with tumor progression.

• Synonyms:

  Semaphorin-3E, Semaphorin-H, Sema H, Sema3e, Semah, Semh

• Gene Name:

  Sema3e

• Gene ID:

  20349

• UniProt:

  P70275

• Chromosomal Location:

  Secreted.

• Applications:

  WB, IHC-P

• Dilution:

  WB--1:1000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation.

• Molecular Weight:

  89543

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SEMA3E Antibody (C-term) [APR13240G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=20349

• Uniprot URL:

  https://www.uniprot.org/uniprot/P70275