LZTS2 Antibody (C-term) [APR31056G]

• Background:

  Tissue Location: Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.

• Synonyms:

  Leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026}, hLZTS2, Protein LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026}, LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026}

• Gene Name:

  LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026}

• Gene ID:

  84445

• UniProt:

  Q9BRK4

• Chromosomal Location:

  Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis

• Applications:

  WB

• Dilution:

  WB--1:1000

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin.

• Molecular Weight:

  72759

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LZTS2 Antibody (C-term) [APR31056G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=84445

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BRK4