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AD16

CAT: 0804-HY-157329Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157329Size:1 Each
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Description
AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC50 of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells[1].
CAS Number
311315-04-5
UNSPSC
12352005
Target
Endonuclease
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ad16.html
Purity
90.0
Smiles
NN1C=NN2C(SCC(CC3=CC=C(C=C3)C4=NC5=CC(NC(CSC6=NN=C7N(C=NN67)N)=O)=CC=C5O4)=O)=NN=C12
Molecular Formula
C24H20N14O3S2
Molecular Weight
616.64
References & Citations
[1]D'Ordine AM, et al. Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease. Nat Commun. 2024;15 (1) :3883. Published 2024 May 8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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