eIF4A3-IN-10

eIF4A3-IN-10

• CAS Number: 1402931-72-9
• UNSPSC Description: eIF4A3-IN-10 (compound 58) is a silvestrol (HY-13251) analogue. eIF4A3-IN-10 interferes the assembling of eIF4F translation complex with EC50s of 35 and 100 nM for myc-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-10 can be used for the research of human cancer pathogenesis[1].
• Target Antigen: Eukaryotic Initiation Factor (eIF)
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/eif4a3-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C([C@@]23OC4=CC(C(NC)=O)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(OC)=O)O)C=C1
• Molecular Weight: 519.54
• References & Citations: [1]Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported