ML 10302 (hydrochloride)

ML 10302 (hydrochloride)

• CAS Number: 186826-17-5
• UNSPSC Description: ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].
• Target Antigen: 5-HT Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/ml-10302-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl
• Molecular Weight: 349.25
• References & Citations: [1]Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.|[2]D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21.|[3]M Cachard-Chastel, et al. 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007 Apr; 150(7): 883–892.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported