Primidone-d5

• Description:

  Primidone-d5 is the deuterium labeled Primidone. Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent[1][2][3].

• UNSPSC:

  12352005

• Target:

  GABA Receptor; Isotope-Labeled Compounds; Necroptosis; RIP kinase; Sodium Channel; TRP Channel

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Purity:

  99.00

• Solubility:

  10 mM in DMSO|DMSO : 50mg/mL (ultrasonic) |H2O : ≥ 0.67mg/mL

• Smiles:

  [2H]C([2H])([2H])C([2H])([2H])C1(C2=CC=CC=C2)C(NCNC1=O)=O

• Molecular Formula:

  C12H9D5N2O2

• Molecular Weight:

  223.28

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kevin Kwong, et al. Voltage-gated sodium channels. Curr Opin Pharmacol. 2015 Jun;22:131-9

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [73738-06-4]