Primidone

CAT: 0804-HY-B0339-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0339-01Size:50 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent[1][2][3].
CAS Number
[125-33-7]
UNSPSC
12352005
Hazard Statement
H302, H351
Target
GABA Receptor; Necroptosis; RIP kinase; Sodium Channel; TRP Channel
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/primidone.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(C1(CC)C2=CC=CC=C2)NCNC1=O
Molecular Formula
C12H14N2O2
Molecular Weight
218.25
Precautions
H302, H351
References & Citations
[1]Krügel U, et al., Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain. 2017 May;158 (5) :856-867.|[2]Riebeling T, et al., Primidone blocks RIPK1-driven cell death and inflammation. Cell Death Differ. 2021 May;28 (5) :1610-1626.|[3]Vogelnik Žakelj K, et al., Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor. Parkinsonism Relat Disord. 2024 Nov;128:107151.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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