Primidone

• Description:

  Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H351

• Target:

  GABA Receptor; Necroptosis; RIP kinase; Sodium Channel; TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/primidone.html

• Purity:

  99.96

• Solubility:

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  O=C(C1(CC)C2=CC=CC=C2)NCNC1=O

• Molecular Formula:

  C12H14N2O2

• Molecular Weight:

  218.25

• Precautions:

  H302, H351

• References & Citations:

  [1]Krügel U, et al., Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain. 2017 May;158 (5) :856-867.|[2]Riebeling T, et al., Primidone blocks RIPK1-driven cell death and inflammation. Cell Death Differ. 2021 May;28 (5) :1610-1626.|[3]Vogelnik Žakelj K, et al., Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor. Parkinsonism Relat Disord. 2024 Nov;128:107151.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [125-33-7]