Fluralaner-d5

• Description :

  Fluralaner-d5 (A1443-d5) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels[1].

• Product Name Alternative :

  A1443-d5; AH252723-d5

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds; Parasite

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Others

• Field of Research :

  Infection

• Smiles :

  O=C(NC([2H])([2H])C(NCC(F)(F)F)=O)C1=CC=C(C2=NOC(C(F)(F)F)(C3=C([2H])C(Cl)=C([2H])C(Cl)=C3[2H])C2)C=C1C

• Molecular Formula :

  C22H12D5Cl2F6N3O3

• Molecular Weight :

  561.32

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275.|[3]Walther FM, et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1 (-/-) Collies after oral administration. Parasit Vectors. 2014 Mar 6;7:86.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported