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MYC antibody

CAT: 0710-FNab10342Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10342Size:100 µg
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Background
MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]
Synonyms
Myc proto-oncogene protein|Class E basic helix-loop-helix protein 39 (bHLHe39) |Proto-oncogene c-Myc|Transcription factor p64|MYC|BHLHE39
UniProt
P01106
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
V-myc myelocytomatosis viral oncogene homolog (avian)
Target
MYC
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism, Immunology, Cancer, Neuroscience, Stem Cells, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50-60 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
1-439aa

UniProtKB · P01106

Myc proto-oncogene protein

MYC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01106
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A024R9L7, A0A087WUS5, A8WFE7, H0YBT0, P01107, Q14026
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative initiationAlternative splicingChromosomal rearrangement

Cellular component

ChromosomeCytoplasmNucleus

Disease

Proto-oncogene

Biological process

TranscriptionTranscription regulation

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