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AM580 (GMP)

CAT: 0804-HY-10475G-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10475G-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AM580 (CD336) (GMP) is AM580= produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist[1][2][3][4].
CAS Number
102121-60-8
Product Name Alternative
CD336 (GMP) ; NSC608001 (GMP) ; Ro 40-6055 (GMP)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RAR/RXR
Type
GMP Small Molecules
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/am580-gmp.html
Purity
99.4
Solubility
10 mM in DMSO
Smiles
CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C
Molecular Formula
C22H25NO3
Molecular Weight
351.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23 (1) :31-45.e7. |[2]Cai A, et al. Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neuron by AM580 Treatment. Neurochem Res. 2022 |[3]Gianní M, et al. AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood. 1996 Feb 15;87 (4) :1520-31.|[4]Brok-Volchanskaya VS, et al. Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA. Stem Cell Reports. 2019 Dec 10;13 (6) :1099-1110.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, protect from light
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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