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KHK-6

CAT: 0804-HY-159123Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159123Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KHK-6 is an inhibitor for serine/threonine kinase hematopoietic progenitor kinase 1 (HPK 1) with an IC50 of 20 nM. KHK-6 enhances CD3/CD28-induced cytokine production, enhances CD69, CD25 and HLA-DR markers on CD4+ and CD8+ T cells, and enhances T cell-mediated killing activity of SKOV3 and A549 cells[1].
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/khk-6.html
Smiles
CC(S(=O)(C1=C(C=CC=C1)NC2=C(C=NC(NC3=CC=C4C(OC(C)(C4=C3)C)=O)=N2)Cl)=O)C
Molecular Formula
C23H23ClN4O4S
Molecular Weight
486.97
References & Citations
[1]Ahn MJ, et al., Novel hematopoietic progenitor kinase 1 inhibitor KHK-6 enhances T-cell activation. PLoS One. 2024 Jun 26;19 (6) :e0305261.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1

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