KHK-IN-1 (hydrochloride)

KHK-IN-1 (hydrochloride)

• CAS Number: 1303470-48-5
• UNSPSC Description: KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity[1].
• Target Antigen: Ketohexokinase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/KHK-IN-1-hydrochloride.html
• Purity: 98.47
• Solubility: DMSO : 25 mg/mL (ultrasonic)|H2O : 14.29 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: [H]Cl.CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5
• Molecular Weight: 459.01
• References & Citations: [1]Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported