KHK-IN-1 (hydrochloride)
CAT:
804-HY-12841A-04
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KHK-IN-1 (hydrochloride)
- CAS Number: 1303470-48-5
- UNSPSC Description: KHK-IN-1 hydrochloride (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%). KHK-IN-1 hydrochloride inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM). KHK-IN-1 hydrochloride has potential for the study of diabetes and obesity[1].
- Target Antigen: Ketohexokinase
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/KHK-IN-1-hydrochloride.html
- Purity: 98.47
- Solubility: DMSO : 25 mg/mL (ultrasonic)|H2O : 14.29 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: [H]Cl.CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5
- Molecular Weight: 459.01
- References & Citations: [1]Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported