Anti-Hu CD34 PE-Cy1537

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

Cat	Name
MBS1800245-02	Anti-Hu CD34 PE
MBS1800216-01	Anti-Hu CD34 PE
MBS1800216-02	Anti-Hu CD34 PE
MBS1800245-01	Anti-Hu CD34 PE
MBS1801497-01	Anti-Hu CD34 PE
MBS1801497-02	Anti-Hu CD34 PE
MBS1800217-02	Anti-Hu CD34 PE-Cyanine7
MBS1800247-02	Anti-Hu CD34 PE-Cyanine5
MBS1800217-01	Anti-Hu CD34 PE-Cyanine7
MBS1800247-01	Anti-Hu CD34 PE-Cyanine5

CAT:

270-T7-297-T100

Size:

100 Tests

Price:

Ask

For price, please contact [email protected].

Anti-Hu CD34 PE-Cy1537

Background: CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
Specifications: The mouse monoclonal antibody 4H11[APG] reacts with extracellular class III epitope on CD34, a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells it is gradually lost on progenitor cells. The antibody 4H11[APG] completely blocks binding of class III antibodies BIRMA K3 and 8G12 on KG1a cell line.
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: Permanent human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia.
Target Antigen: CD34
Isotype: IgG1
Clone: 4H11[APG]
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: PE-Cy1537
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Elknerová K, Lacinová Z, Soucek J, Marinov I, Stöckbauer P: Growth inhibitory effect of the antibody to hematopoietic stem cell antigen CD34 in leukemic cell lines. Neoplasma. 200754(4):311-20., URL: http://www.ncbi.nlm.nih.gov/pubmed/17822321?itool=,
Other References: *Krauter J, Hartl M, Hambach L, Kohlenberg A, Gunsilius E, Ganser A, Heil G: Receptor-mediated endocytosis of CD34 on hematopoietic cells after stimulation with the monoclonal antibody anti-HPCA-1. J Hematother Stem Cell Res. 2001 Dec10(6):863-71., URL: http://www.ncbi.nlm.nih.gov/pubmed/11798512?ordina,*Dao MA, Arevalo J, Nolta JA: Reversibility of CD34 expression on human hematopoietic stem cells that retain the capacity for secondary reconstitution. Blood. 2003 Jan 1101(1):112-8., URL: http://www.ncbi.nlm.nih.gov/pubmed/12393633?ordina,*Gangenahalli GU, Singh VK, Verma YK, Gupta P, Sharma RK, Chandra R, Gulati S, Luthra PM: Three-dimensional structure prediction of the interaction of CD34 with the SH3 domain of Crk-L. Stem Cells Dev. 2005 Oct14(5):470-7., URL: http://www.ncbi.nlm.nih.gov/pubmed/16305332?ordina,*Gangenahalli GU, Singh VK, Verma YK, Gupta P, Sharma RK, Chandra R, Luthra PM: Hematopoietic stem cell antigen CD34: role in adhesion or homing. Stem Cells Dev. 2006 Jun15(3):305-13., URL: http://www.ncbi.nlm.nih.gov/pubmed/16846369?ordina,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD34 PE-Cy1537, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

Find us on

Cat	Name
T7-297-T025	Anti-Hu CD34 PE-Cy1537
T7-297-T100	Anti-Hu CD34 PE-Cy1537
T7-208-T100	Anti-Hu CD9 PE-Cy1537
T7-503-T100	Anti-Hu CD24 PE-Cy1537
T7-676-T100	Anti-Hu CD79b PE-Cy1537
T7-146-T100	Anti-Hu CD184 PE-Cy1537
T7-173-T025	Anti-Hu CD3 PE-Cy1537
T7-178-T100	Anti-Hu CD273 PE-Cy1537
T7-218-T025	Anti-Hu CD25 PE-Cy1537
T7-287-T025	Anti-Hu CD80 PE-Cy1537