Anti-Hu CD273 PE-Cy1537

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

Cat	Name
MBS1800100-02	Anti-Hu CD273 PE
MBS1800100-01	Anti-Hu CD273 PE
MBS1800101-01	Anti-Hu CD273 PE-Cyanine7
MBS1800101-02	Anti-Hu CD273 PE-Cyanine7
MBS1800099-02	Anti-Hu CD273 APC
MBS1800098-02	Anti-Hu CD273 Purified
MBS1800098-01	Anti-Hu CD273 Purified
MBS1800099-01	Anti-Hu CD273 APC
MBS1802012-INQUIRE	Anti-Hu CD273 Alexa Fluor647
MBS1800008-02	Anti-Hu CD64 PE

CAT:

270-T7-178-T100

Size:

100 Tests

Price:

Ask

For price, please contact [email protected].

Anti-Hu CD273 PE-Cy1537

Background: CD273 / PD-L2 (programmed death ligand-1), also known as B7-DC, is a member of the B7 family of regulatory proteins. It costimulates the proliferation of T cells, and mediates IFN gamma production. Ligation of CD273 on dendritic cells enhances dendritic cell activation and T cell responses. When interacting with CD279, it can act as a coinhibitor of the T cell function. CD273 expression is a useful marker to distinguish primary mediastinal B cell lymphoma from other diffuse large B cell lymphomas.
Specifications: The mouse monoclonal antibody 24F.10C12 recognizes an extracellular epitope of CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin´s lymphoma cells and primary mediastinal B cell lymphoma (PMBL).
Certification: RUO
Host: Mouse
Species Reactivity: Human
Immunogen: human CD273 cDNA
Target Antigen: CD273
Isotype: IgG2a κ
Clone: 24F.10C12
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: PE-Cy1537
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28116(17):3268-77., URL: http://www.ncbi.nlm.nih.gov/pubmed/20628145,*Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr89(4):507-15., URL: https://pubmed.ncbi.nlm.nih.gov/21097698/,*Semnani RT, Mahapatra L, Moore V, Sanprasert V, Nutman TB: Functional and phenotypic characteristics of alternative activation induced in human monocytes by interleukin-4 or the parasitic nematode Brugia malayi. Infect Immun. 2011 Oct79(10):3957-65., URL: http://www.ncbi.nlm.nih.gov/pubmed/21788379 ,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD273 PE-Cy1537, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

Find us on

Cat	Name
T7-178-T100	Anti-Hu CD273 PE-Cy1537
1P-178-T025	Anti-Hu CD273 PE
1P-178-T100	Anti-Hu CD273 PE
T7-146-T100	Anti-Hu CD184 PE-Cy1537
T7-173-T025	Anti-Hu CD3 PE-Cy1537
T7-218-T025	Anti-Hu CD25 PE-Cy1537
T7-287-T025	Anti-Hu CD80 PE-Cy1537
T7-287-T100	Anti-Hu CD80 PE-Cy1537
T7-305-T025	Anti-Hu CD19 PE-Cy1537
T7-359-T100	Anti-Hu CD4 PE-Cy1537