Anti-Hu CD274 Alexa Fluor® 700

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

Alternative Products

Cat	Name
MBS1802060-INQUIRE	Anti-Hu CD274 Alexa Fluor700
MBS1800108-01	Anti-Hu CD274 FITC
MBS1800107-02	Anti-Hu CD274 APC
MBS1800109-01	Anti-Hu CD274 PE
MBS1800109-02	Anti-Hu CD274 PE
MBS1800108-02	Anti-Hu CD274 FITC
MBS1800107-01	Anti-Hu CD274 APC
MBS1800105-01	Anti-Hu CD274 Purified
MBS1800105-02	Anti-Hu CD274 Purified
MBS1800110-01	Anti-Hu CD274 PE-Cyanine7

CAT:

270-A7-177-T100

Size:

100 Tests

Price:

Ask

For price, please contact [email protected].

Anti-Hu CD274 Alexa Fluor® 700

Background: CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its receptor CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor(s) for CD274 is likely.
Specifications: The mouse monoclonal antibody 29E.2A3 recognizes an extracellular epitope of CD274 / PD-L1 (also known as B7-H1), a 40 kDa type I transmembrane protein expressed by dendritic cells, activated T cells, activated monocytes, and in various tissues, above all in heart and skeletal muscle, placenta and lung, and in many cancer cells, including T cell lymphomas, melanomas, and glioblastomas.
Certification: RUO
Host: Mouse
Species Reactivity: Non-human primates, Human
Immunogen: Full length human CD274
Target Antigen: CD274
Isotype: IgG2b κ
Clone: 29E.2A3
Applications: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests.
Validated Applications: FC
Format: Alexa Fluor® 700
Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr89(4):507-15., URL: https://pubmed.ncbi.nlm.nih.gov/21097698/,*Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28116(17):3268-77., URL: http://www.ncbi.nlm.nih.gov/pubmed/20628145 ,*Haile ST, Dalal SP, Clements V, Tamada K, Ostrand-Rosenberg S: Soluble CD80 restores T cell activation and overcomes tumor cell programmed death ligand 1-mediated immune suppression. J Immunol. 2013 Sep 1191(5):2829-36., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=haile+st+dalal+sp+clements+v ,*Haile ST, Bosch JJ, Agu NI, Zeender AM, Somasundaram P, Srivastava MK, Britting S, Wolf JB, Ksander BR, Ostrand-Rosenberg S: Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80. J Immunol. 2011 Jun 15186(12):6822-9., URL: https://pubmed.ncbi.nlm.nih.gov/21555531/,
Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Complementary Product Range

Our range of products, including Anti-Hu CD274 Alexa Fluor® 700, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

Each item in our collection, is tested for precision and quality, ensuring dependable solutions for your research. As we continue to incorporate the latest advancements, Gentaur ensures that our product range remains relevant and versatile, providing you with the tools needed for both current and future projects.

Find us on

Cat	Name
A7-177-T100	Anti-Hu CD274 Alexa Fluor® 700
11-177-C100	Anti-Hu CD274 Purified
1P-177-T100	Anti-Hu CD274 PE
1P-177-T025	Anti-Hu CD274 PE
11-177-C025	Anti-Hu CD274 Purified
1A-177-T100	Anti-Hu CD274 APC
1F-177-T100	Anti-Hu CD274 FITC
T9-177-T100	Anti-Hu CD274 PerCP-Cy1535.5
T7-177-T100	Anti-Hu CD274 PE-Cy1537
12-177-C100	Anti-Hu CD274 Purified Low Endotoxin