Anti-Hu CD274 Purified

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MBS1800109-02	Anti-Hu CD274 PE

CAT:

270-11-177-C100

Size:

0.1 mg

Price:

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Anti-Hu CD274 Purified

Background: CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its receptor CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor(s) for CD274 is likely.
Specifications: The mouse monoclonal antibody 29E.2A3 recognizes an extracellular epitope of CD274 / PD-L1 (also known as B7-H1), a 40 kDa type I transmembrane protein expressed by dendritic cells, activated T cells, activated monocytes, and in various tissues, above all in heart and skeletal muscle, placenta and lung, and in many cancer cells, including T cell lymphomas, melanomas, and glioblastomas.
Certification: RUO
Host: Mouse
Species Reactivity: Non-human primates, Human
Immunogen: Full length human CD274
Target Antigen: CD274
Isotype: IgG2b κ
Clone: 29E.2A3
Applications: Immunohistochemistry (frozen sections): Acetone fixation. Flow cytometry: Recommended dilution: 1-4 µg/mL
Validated Applications: FC, IHC-F
Concentration: 1 mg/mL
Format: Purified
Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations: *Rodríguez-García M, Porichis F, de Jong OG, Levi K, Diefenbach TJ, Lifson JD, Freeman GJ, Walker BD, Kaufmann DE, Kavanagh DG: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10. J Leukoc Biol. 2011 Apr89(4):507-15., URL: https://pubmed.ncbi.nlm.nih.gov/21097698/,*Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Oct 28116(17):3268-77., URL: http://www.ncbi.nlm.nih.gov/pubmed/20628145 ,*Haile ST, Dalal SP, Clements V, Tamada K, Ostrand-Rosenberg S: Soluble CD80 restores T cell activation and overcomes tumor cell programmed death ligand 1-mediated immune suppression. J Immunol. 2013 Sep 1191(5):2829-36., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=haile+st+dalal+sp+clements+v ,*Haile ST, Bosch JJ, Agu NI, Zeender AM, Somasundaram P, Srivastava MK, Britting S, Wolf JB, Ksander BR, Ostrand-Rosenberg S: Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80. J Immunol. 2011 Jun 15186(12):6822-9., URL: https://pubmed.ncbi.nlm.nih.gov/21555531/,
Storage Conditions: Store at 2-8°C. Do not freeze.

Complementary Product Range

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Cat	Name
11-177-C100	Anti-Hu CD274 Purified
11-177-C025	Anti-Hu CD274 Purified
12-177-C100	Anti-Hu CD274 Purified Low Endotoxin
1P-177-T100	Anti-Hu CD274 PE
1P-177-T025	Anti-Hu CD274 PE
1A-177-T100	Anti-Hu CD274 APC
1F-177-T100	Anti-Hu CD274 FITC
T9-177-T100	Anti-Hu CD274 PerCP-Cy1535.5
T7-177-T100	Anti-Hu CD274 PE-Cy1537
11-131-C025	Anti-Hu CD109 Purified