Anti-Lysozyme PE

• Description:

  Lysozyme is anti-bacterial enzyme found mainly in milk, saliva, tears, plasma, spleen, mucus, and leukocytes (e.g. in cytoplasmic granules of neutrophils) . It damages bacterial cell walls by hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Lysozyme is part of the innate immune system. It protects wet body surfaces, such as conjunctiva. Reduced lysozyme levels have been associated with bronchopulmonary dysplasia in newborns. On the other hand high lysozyme blood levels produced for example by myelomonocytic leukemia cells can lead to kidney failure and low blood potassium.

• Certification:

  RUO

• Immunogen:

  Human lysozyme

• Target Antigen:

  Lysozyme

• Clone:

  LZ598-10G9

• Applications:

  FC-IC (QC tested)

• Concentration:

  0.1 mg/mL

• Format:

  PE

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Other References:

  *Strobl H, Knapp W: Myeloid cell-associated lysosomal proteins as flow cytometry markers for leukocyte lineage classification. J Biol Regul Homeost Agents. 2004 Jul-Dec;18 (3-4) :335-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/15786701

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The mouse monoclonal antibody LZ598-10G9 recognizes lysozyme, an approximately 17 kDa antibacterial enzyme, which is being used as a marker for the lineage diagnosis of acute leukemias (intracellular antigen) .

• Applications Notes:

  Flow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.

• Species:

  Human

• CAS Number:

  9007-83-4

• Isotype:

  Mouse IgG1