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Anti-Hu CD54 PE

CAT: 0270-1P-429-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1P-429-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD54 (ICAM-1) is a 90 kD member of the C2 subset of immunoglobulin superfamily. It is a transmembrane molecule with 7 potential N-glycosylated sites, expressed on resting monocytes and endothelial cells and can be upregulated on many other cells, e.g. with lymphokines, on B- and T-lymphocytes, thymocytes, dendritic cells and also on keratinocytes, chondrocytes, as well as epithelial cells. CD54 mediates cell adhesion by binding to integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1) . The interaction of CD54 with LFA-1 enhances antigen-specific T-cell activation.
Certification
RUO
Reactivity
Human
Immunogen
Raji cells and spleen cells fused with NS1 cells
Target Antigen
CD54
Clone
1H4
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Williams DT, Chaudhry Y, Goodfellow IG, Lea S, Evans DJ: Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites. J Gen Virol. 2004 Mar;85 (Pt 3) :731-8. , URL: https://www.ncbi.nlm.nih.gov/pubmed/14993659?dopt=
Other References
*Boyd AW, Wawryk SO, Burns GF, Fecondo JV: Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms. Proc Natl Acad Sci U S A. 1988 May;85 (9) :3095-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/3362863?dopt=A, *Boyd AW, Dunn SM, Fecondo JV, Culvenor JG, Duhrsen U, Burns GF, Wawryk SO: Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation. Blood. 1989 May 15;73 (7) :1896-903., URL: https://www.ncbi.nlm.nih.gov/pubmed/2469503?dopt=A, *Springer TA: Adhesion receptors of the immune system. Nature. 1990 Aug 2;346 (6283) :425-34., URL: https://www.ncbi.nlm.nih.gov/pubmed/1974032?dopt=A, *Ockenhouse CF, Betageri R, Springer TA, Staunton DE: Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus. Cell. 1992 Jan 10;68 (1) :63-9. Erratum in: Cell 1992 Mar 6;68 (5) :following 994., URL: https://www.ncbi.nlm.nih.gov/pubmed/1346257?dopt=A
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The antibody 1H4 recognizes an extracellular epitope of CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus) expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells; the expression of CD54 is upregulated by activation.
Applications Notes
6
Isotype
Mouse IgG2b

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