Anti-Hu CD39 PE

CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), is a cell surface enzyme (with intracellular N- and C-terminus) which hydrolyzes extracellular ATP and ADP to AMP. Inhibition of its enzymatic activity may confer anticancer benefits. The formation of oligomers in the plasma membrane is essential for enzyme activity. It is expressed on Treg cells, and in other cell types, such as mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets. Hydrolysis of ATP and ADP inhibits inflammatory and thrombotic responses. In the nervous system, it regulates purinergic neurotransmission.

Human

CD39

TU66

FC (QC tested)

PE

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, Giometto R, Höpner S, Centonze D, Bernardi G, Dell'Acqua ML, Rossini PM, Battistini L, Rötzschke O, Falk K: Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 2007 Aug 15;110 (4) :1225-32., URL: http://www.ncbi.nlm.nih.gov/pubmed/17449799 , *Nikolova M, Carriere M, Jenabian MA, Limou S, Younas M, Kök A, Huë S, Seddiki N, Hulin A, Delaneau O, Schuitemaker H, Herbeck JT, Mullins JI, Muhtarova M, Bensussan A, Zagury JF, Lelievre JD, Lévy Y: CD39/adenosine pathway is involved in AIDS progression. PLoS Pathog. 2011 Jul;7 (7) :e1002110., URL: http://www.ncbi.nlm.nih.gov/pubmed/21750674 , *Wang YM, McRae JL, Robson SC, Cowan PJ, Zhang GY, Hu M, Polhill T, Wang Y, Zheng G, Wang Y, Lee VW, Unwin RJ, Harris DC, Dwyer KM, Alexander SI: Regulatory T cells participate in CD39-mediated protection from renal injury. Eur J Immunol. 2012 Sep;42 (9) :2441-51., URL: https://pubmed.ncbi.nlm.nih.gov/22684996/, *Gadeock S, Tran JN, Georgiou JG, Jalilian I, Taylor RM, Wiley JS, Sluyter R: TGF-β1 prevents up-regulation of the P2X7 receptor by IFN-γ and LPS in leukemic THP-1 monocytes. Biochim Biophys Acta. 2010 Nov;1798 (11) :2058-66., URL: https://pubmed.ncbi.nlm.nih.gov/19351909/, *Jin Z, Teramoto N, Hayashi K, Liu YX, Jin G, Oka T, Takahashi K, Yoshino T, Akagi T: CD40 ligand stimulation inhibits the proliferation of mantle cell lymphoma lines. Anticancer Res. 2004 Mar-Apr;24 (2B) :691-7., URL: http://www.ncbi.nlm.nih.gov/pubmed/15161013, *Virtanen S, Schulte R, Stingl J, Caldas C, Shehata M: High-throughput surface marker screen on primary human breast tissues reveals further cellular heterogeneity. Breast Cancer Res. 2021 Jun 13;23 (1) :66., URL: https://pubmed.ncbi.nlm.nih.gov/34120626/

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

The mouse monoclonal antibody TU66, also known as Tü66, recognizes an extracellular epitope of CD39, a 78 kDa cell surface enzyme expressed by regulatory T cells, mantle zone B cells, activated T cells, NK cells, macrophages, dendritic cells, neurons, endothelial cells and platelets.

6