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Anti-PCNA PE

CAT: 0270-1P-182-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1P-182-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PCNA (proliferating cell nuclear antigen) is the DNA polymerase delta auxiliary protein acting in homotrimeric form to increase the processivity of leading strand synthesis during DNA replication. PCNA is expressed in the nucleus of all proliferating cells. In response to DNA damage, it is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. PCNA is a useful marker of DNA synthesis, as its form not involved in DNA synthesis degradates in histological preparations in the presence of organic solvents.
Certification
RUO
Reactivity
Mouse, Human, Non-human primates, Drosophila, Chicken, Rat
Immunogen
Recombinant rat PCNA
Target Antigen
PCNA
Clone
PC10
Applications
FC-IC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Dahm K, Hübscher U: Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block. Oncogene. 2002 Oct 31;21 (50) :7710-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=dahm+k+hubscher+u , *Malkas LH, Herbert BS, Abdel-Aziz W, Dobrolecki LE, Liu Y, Agarwal B, Hoelz D, Badve S, Schnaper L, Arnold RJ, Mechref Y, Novotny MV, Loehrer P, Goulet RJ, Hickey RJ: A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker. Proc Natl Acad Sci U S A. 2006 Dec 19;103 (51) :19472-7., URL: https://pubmed.ncbi.nlm.nih.gov/17159154/, *Landberg G, Roos G: Antibodies to proliferating cell nuclear antigen as S-phase probes in flow cytometric cell cycle analysis. Cancer Res. 1991 Sep 1;51 (17) :4570-4., URL: http://www.ncbi.nlm.nih.gov/pubmed/1678682
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody PC10 (also known as 3F81) recognizes PCNA, a 36 kDa conserved nuclear protein serving as a cofactor for DNA synthesis.
Applications Notes
6
Isotype
Mouse IgG2a kappa

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